The Cannabinoid System

What is the endocannabinoid system?

The endocannabinoid system (ECS) is a complex cell-signaling system identified in the early 1990s by researchers exploring THC, a well-known cannabinoid. Cannabinoids are compounds found in many plants including just to name a few – Flax, Hops, Hemp, and Cannabis.

Experts are still trying to fully understand the ECS. But so far, we know it plays role in regulating a range of functions and processes, including:

Sleep
Pain
Mood
Appetite
Memory
Reproduction and fertility

The ECS exists and is active in your body even if you don’t use or consume products containing cannabinoids.

How does it work?

The ECS involves three core components: endocannabinoids, receptors, and enzymes.

Endocannabinoids

Endocannabinoids, also called endogenous cannabinoids, are molecules made by your body. They’re similar to cannabinoids, but they’re produced by your body. Experts have identified two key endocannabinoids so far:

Anandamide (AEA)
2-arachidonoylglyerol (2-AG)

These help keep internal functions running smoothly. Your body produces them as needed, making it difficult to know what typical levels are for each.

Endocannabinoid Receptors

These receptors are found throughout your body. Endocannabinoids bind to them in order to signal that the ECS needs to take action.

There are two main endocannabinoid receptors:

CB1 receptors, which are mostly found in the central nervous system
CB2 receptors, which are mostly found in your peripheral nervous system, especially immune cells

Endocannabinoids can bind to either receptor. The effects that result depend on where the receptor is located and which endocannabinoid it binds to.

For example, endocannabinoids might target CB1 receptors in a spinal nerve to relieve pain. Others might bind to a CB2 receptor in your immune cells to signal that your body’s experiencing inflammation, a common sign of autoimmune disorders.

The role that Enzymes play

Enzymes are responsible for breaking down endocannabinoids once they’ve carried out their function.

There are two main enzymes responsible for this:

Fatty acid amide hydrolase, which breaks down AEA
Monoacylglycerol acid lipase, which typically breaks down 2-AG

What are its functions?

The ECS is complicated, and experts haven’t yet determined exactly how it works or all of its potential functions. Research has linked the ECS to the following processes:

Appetite and digestion
Metabolism
Chronic pain
Inflammation and other immune system responses
Mood
Learning and memory
Motor control
Sleep
Cardiovascular system function
Muscle formation
Bone remodeling and growth
Liver function
Reproductive system function
Stress
Skin and nerve function

These functions all contribute to homeostasis, which refers to the stability of your internal environment. For example, if an outside force, such as pain from an injury or a fever, throws off your body’s homeostasis, your ECS kicks in to help your body return to its ideal operation.

Today, experts believe that maintaining homeostasis is the primary role of the ECS

How does CBD interact with the ECS?

CBD is the major cannabinoid found in Hemp. Unlike THC, CBD doesn’t make you “high” and typically doesn’t cause any negative effects.

Experts aren’t completely sure how CBD interacts with the ECS. But they do know that it doesn’t bind to CB1 or CB2 receptors the way THC does.

Instead, many believe it works by preventing endocannabinoids from being broken down. This allows them to have more of an effect on your body. Others believe that CBD binds to a receptor that hasn’t been discovered yet.

While the details of how it works are still under debate, research suggests that CBD can help with pain, nausea, and other symptoms associated with multiple conditions.

What about endocannabinoid deficiency?

Some experts believe in a theory known as clinical endocannabinoid deficiency (CECD). This theory suggests that low endocannabinoid levels in your body or ECS dysfunction can contribute to the development of certain conditions.

A 2016 article (add link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576607/ ) reviewing over 10 years of research on the subject suggests the theory could explain why some people develop a migraine, fibromyalgia, and irritable bowel syndrome.

None of these conditions have a clear underlying cause. They’re also often resistant to treatment and sometimes occur alongside each other.

If CECD does play any kind of role in these conditions, targeting the ECS or endocannabinoid production could be the missing key to treatment, but more research is needed. The ECS plays a big role in keeping your internal processes stable. But there’s still a lot we don’t know about it. As experts develop a better understanding of the ECS, it could eventually hold the key to treating several conditions.